Biosynthetic Gene Clusters

The NaPDoS version 2 reference database includes 417 PKS (including 13 FAS), NRPS, and hybrid biosynthetic gene clusters (BGCs) with chemically characterized products, encompassing 2150 manually curated and trimmed KS and C domain amino acid sequences. Click on individual BGC product names below to see more detailed descriptions, including chemical structures.

A tab-delimited text version of this table and links to PKS and NRPS domain sequences in fasta format are available for DOWNLOAD below.


BGC product name ⇅ BGC type ⇅ MIBiG ID ⇅ PubMed ID ⇅
1,3,6,8-tetrahydroxynaphthalene PKS BGC0001257 10628853
6-methylsalicylic acid Aspergillus sp. PKS BGC0001276 9003280
6-methylsalicylic acid Glarea sp. PKS BGC0001275 15800788
9-methylstreptimidone PKS BGC0000171 23438151
A-74528 PKS BGC0000190 23442197
aclacinomycin PKS BGC0000192 12137949
actinorhodin PKS BGC0000194 19246012
Aetherobacter polyunsaturated fatty acid PKS na 10.1039/C3SC53163E
aflatoxin PKS BGC0000004 16391082
Aliivibrio fischeri aryl polyene PKS BGC0000837 25036635
alnumycin PKS BGC0000195 18940666
alternariol PKS BGC0000013 22510154
ambruticin PKS BGC0000014 17185223
amphotericin PKS BGC0000016 11451671
anatoxin PKS BGC0000017 21873484
annimycin PKS BGC0001298 24120331
ansamitocin PKS BGC0000020 12060743
anthrabenzoxocinone PKS BGC0001512 29227089
apoptolidin PKS BGC0000021 21869849
aranciamycin PKS BGC0000197 17357167
arcuflavin PKS na 24618669
arenimycin PKS BGC0000198 24191063
ascomycin PKS BGC0000994 10863099
asparasone PKS BGC0001446 24412484
asperfuranone PKS BGC0000022 19199437
asperlactone PKS BGC0001273 19589392
asperthecin PKS BGC0000684 18978088
asukamycin PKS BGC0000187 20522559
aurachin PKS BGC0001343 26473393
aureothin PKS BGC0000024 14700630
austinol PKS na 22329759
avermectin PKS BGC0000025 10449723
avilamycin PKS BGC0000026 11410376
azalomycin PKS BGC0001523 28418225
azicemicin PKS BGC0000202 19928906
bafilomycin PKS BGC0000028 23663353
BE-14106 PKS BGC0000029 19875084
benastatin PKS BGC0000204 17439117
bikaverin PKS BGC0000030 23825955
bongkrekic acid PKS BGC0000173 22999884
borrelidin PKS BGC0000031 15112998
botcinic acid PKS na 21722295
brefeldin PKS BGC0001141 24845309
bryostatin PKS BGC0000174 17253852
byssochlamic acid PKS BGC0001340 27099957
calcimycin PKS BGC0000032 21173184
calicheamicin PKS BGC0000033 12183629
candicidin PKS BGC0000034 14652074
cercosporin PKS na 17462021
cervimycin PKS BGC0001439 29441046
chaetoviridin PKS BGC0001405 23072467
chalcomycin PKS BGC0000035 15561847
chartreusin PKS BGC0000206 15911378
chelocardin PKS BGC0000208 24043447
chivosazol PKS BGC0001069 16313990
chlorizidine PKS BGC0001172 24246014
chlorothricin PKS BGC0000036 16793515
chlortetracycline PKS BGC0000209 23800859
chromomycin PKS BGC0000210 15112992
chrysomycin PKS BGC0000211 20140934
citrinin PKS BGC0001338 29899939
colabomycin PKS BGC0000213 24838618
compactin PKS BGC0000039 12172803
concanamycin PKS BGC0000040 16207901
corallopyronin PKS BGC0001091 20503218
cornexistin PKS BGC0001557 28660939
coronafacic acid PKS BGC0000041 9860992
cosmomycin PKS BGC0000214 16810496
cremimycin PKS BGC0000042 24014395
Cryptosporidium parvum PKS PKS na 12406578
cuevaene PKS na 23824670
cyanosporaside PKS na 23458364
Cyanothece sp olefin synthase PKS BGC0001164 24475038
cycloheximide PKS BGC0000175 24815182
cylindrocyclophane PKS BGC0001064 23106426
cytorhodin PKS BGC0001568 28971684
dehydrocurvularin PKS BGC0000045 23335766
depudecin PKS BGC0000046 19737099
differentiation-inducing factor PKS na 16906151
difficidin PKS BGC0000176 16707694
divergolide PKS BGC0001119 24768719
dothistromin PKS BGC0000048 16649078
doxorubicin PKS BGC0000218 7828855
dynemicin PKS BGC0001060 18328078
ebelactone PKS BGC0000051 23801186
ECO-02301 PKS BGC0000052 15844935
ECO-0501 PKS na 17136886
elansolid PKS BGC0000178 21472917
elloramycin PKS BGC0000219 18310024
elsinochrome PKS na 18957608
endocrocin PKS BGC0001118 22492455
enterocin PKS BGC0000220 11137817
erdacin PKS BGC0000221 19621341
erythromycin PKS BGC0000055 11336289
Escherichia coli aryl polyene PKS BGC0000836 25036635
esmeraldin PKS BGC0000935 22999880
esperamicin PKS BGC0000056 14528002
fasamycin PKS na 22224500
FD-594 PKS BGC0000222 21102601
FD-891 PKS BGC0000058 20589823
flexirubin PKS BGC0000839 24467333
fluostatin PKS BGC0000223 20690632
fluvirucin PKS BGC0001597 26818633
fostriecin PKS BGC0000060 23352138
fredericamycin PKS BGC0000224 16305230
frenolicin PKS BGC0000225 8181754
fumagillin PKS BGC0001067 23488861
fumonisin PKS BGC0000062 21315309
furanone PKS na 16724457
fusarielin PKS BGC0001600 27983606
fusarubin PKS BGC0001242 22492438
geldanamycin PKS BGC0000066 12586396
gephyronic acid PKS BGC0000069 24298873
gilvocarcin PKS BGC0000226 12822997
granaticin PKS BGC0000228 2583128
griseofulvin PKS BGC0000070 20534346
griseorhodin PKS BGC0000230 12323376
griseusin PKS BGC0000231 8169211
halstoctacosanolide PKS BGC0000073 16568718
hatomarubigin PKS BGC0000232 20453135
hedamycin PKS BGC0000233 15271354
herbimycin PKS BGC0000074 16085885
herboxidiene PKS BGC0001065 22247174
hitachimycin PKS BGC0001194 25786909
hypothemycin PKS BGC0000076 18567690
incednine PKS BGC0000078 23921821
indanomycin PKS BGC0000079 19301315
ishigamide PKS BGC0001623 27311327
isofuranonaphthoquinone PKS BGC0001625 27731333
isotropolone PKS BGC0001622 28371116
jadomycin PKS BGC0000234 7881555
jawsamycin PKS BGC0001002 24756819
jerangolid PKS BGC0000080 17185223
kendomycin PKS BGC0001066 18972512
kinamycin PKS BGC0000236 21193612
kosinostatin PKS BGC0001073 23790490
L-155,175 PKS na 22669556
lactimidomycin PKS BGC0000083 25405956
lactonamycin PKS BGC0000238 18070976
landomycin PKS BGC0000239 9933932
lankamycin PKS BGC0000085 12791134
lasalocid PKS BGC0000086 19129623
lomaiviticin PKS BGC0000240 25045187
lovastatin PKS na 10334994
lymphostin PKS BGC0001006 21815669
lysolipin PKS BGC0000242 20399259
macrolactin PKS BGC0000181 17844999
maduropeptin PKS BGC0001008 17918933
mayamycin PKS BGC0001661 29515228
medermycin PKS BGC0000245 12855716
megalomicin PKS BGC0000092 10972798
meilingmycin PKS BGC0000093 20348291
melanin PKS na 7500937
Melopsittacus undulatus PKS PKS na 28985565
mensacaricin PKS BGC0001177 22162248
meridamycin PKS BGC0001012 17159202
migrastatin PKS BGC0000177 19726666
mithramycin PKS BGC0000247 8807845
mitorubrinol PKS na 23094121
monacolin PKS BGC0000098 19968298
monensin PKS BGC0000100 12940979
Moorea bouillonii olefin synthase PKS BGC0001161 24475038
Moorea producens olefin synthase PKS BGC0001162 24475038
Moritella polyunsaturated fatty acid PKS BGC0000864 16859689
mupirocin PKS BGC0000182 12770824
murayaquinone PKS BGC0001675 28712746
mycinamicin PKS BGC0000102 12583909
mycocerosic acid PKS na 1527058
mycolactone PKS BGC0000103 14617651
mycophenolic acid PKS BGC0000104 21398490
nanchangmycin PKS BGC0000105 12770825
naphthocyclinone PKS BGC0000248 10206788
naphthomycin PKS BGC0000106 21614382
naphthopyrone PKS BGC0000107 19146970
nenestatin PKS BGC0001693 10.1016/j.tet.2017.03.054
neocarzinostatin PKS BGC0000112 15797213
niddamycin PKS BGC0000113 9393718
nigericin PKS BGC0000114 17584617
nogalamycin PKS BGC0000249 8668120
nonactin PKS BGC0000252 10650222
nystatin PKS BGC0000115 10873841
ochratoxin PKS BGC0001030 15368856
oleandomycin PKS na 10908114
oligomycin PKS BGC0000117 11572948
Oryzias latipes PKS PKS na 26605048
oviedomycin PKS BGC0000253 15368568
oxazolomycin PKS BGC0001106 16707707
oxytetracycline PKS BGC0000254 16597959
pactamycin PKS BGC0000118 17827660
pamamycin PKS BGC0001150 25537663
paramagnetoquinone PKS BGC0001730 28218529
patellazole PKS na 23185008
patulin PKS BGC0000120 25120234
PD116740 PKS na 8990300
phoslactomycin PKS BGC0000123 12819191
Photobacterium polyunsaturated fatty acid PKS BGC0000865 12055309
piericidin PKS BGC0000124 22365607
pikromycin PKS BGC0000094 9770448
pimaricin PKS BGC0000125 11094342
pladienolide PKS BGC0000126 18997414
polyketomycin PKS BGC0001061 19266534
pradimicin PKS BGC0000256 18051306
Pseudoalteromonas polyunsaturated fatty acid PKS BGC0000863 17122401
pyoluteorin PKS BGC0000127 10094695
pyralomicin PKS BGC0001038 23607523
pyrrolomycin PKS BGC0000130 17158935
quartromicin PKS BGC0000133 23102224
R-mellein PKS na 22793256
R1128 PKS BGC0000261 10931852
radicicol PKS BGC0000134 18567690
resistomycin PKS BGC0000264 14982421
reveromycin PKS BGC0000135 21642985
rifamycin PKS BGC0000136 9512878
ripostatin PKS BGC0001761 28098952
rishirilide PKS BGC0001179 22162248
rubradirin PKS BGC0000141 9387157
rubrolone PKS BGC0001762 27713400
rubromycin PKS BGC0000266 25798711
salinilactam PKS BGC0000142 17563368
salinomycin PKS BGC0000144 22156425
saquayamycin PKS BGC0000267 17497146
sceliphrolactam PKS BGC0001770 29371699
Sch 47554 PKS BGC0000268 17085966
Schizochytrium polyunsaturated fatty acid PKS na 11452122
SF2575 PKS BGC0000269 19908837
Shewanella polyunsaturated fatty acid PKS na 20458400
SIA7248 PKS na 23505159
simocyclinone PKS BGC0001072 11959542
solanapyrone PKS BGC0000146 20486243
sorangicin PKS BGC0000184 20715267
soraphen PKS BGC0000147 12039053
spinosyn PKS BGC0000148 11358695
spirangien PKS BGC0000149 17317575
squalestatin PKS BGC0001339 27056201
stambomycin PKS BGC0000151 21444795
steffimycin PKS BGC0000273 16751529
sterigmatocystin PKS BGC0000152 7642507
stigmatellin PKS BGC0000153 11809757
stipitatic acid PKS BGC0000154 22508998
Streptomyces avermitilis spore pigment PKS BGC0000271 11572948
Streptomyces coelicolor spore pigment PKS na 2077356
Streptomyces collinus spore pigment PKS BGC0000272 11372781
streptophenazine PKS BGC0002010 30853419
Strongylocentrotus purpuratus PKS1 PKS na 17207587
Strongylocentrotus purpuratus PKS2 PKS na 17207587
swinholide PKS BGC0001795 29150506
Synechococcus sp olefin synthase PKS BGC0001160 21531827
T-toxin PKS na 8953776
TAN-1612 PKS BGC0000156 21866960
tartrolon PKS BGC0000185 23288898
tautomycetin PKS BGC0000157 17379718
terreic acid PKS BGC0000160 25265334
terretonin PKS BGC0000682 23116177
tetracenomycin PKS BGC0000275 1548230
tetronomycin PKS BGC0000164 18404760
tiacumicin PKS BGC0000165 21186805
tylactone PKS BGC0000166 11816964
urdamycin PKS na 7592377
vicenistatin PKS BGC0000167 15112997
viridicatumtoxin PKS BGC0000168 20534346
warkmycin PKS BGC0001438 29441046
wortmanamide PKS BGC0001954 29343058
xantholipin PKS BGC0000279 22444597
xanthomonadin PKS na 29995983
yanuthone PKS BGC0000170 24684908
actinomycin NRPS BGC0000296 20304989
anabaenopeptilide NRPS na 10931313
arthrofactin NRPS BGC0000305 14522057
bacillibactin NRPS BGC0000309 11112781
bacitracin NRPS BGC0000310 9427658
balhimycin NRPS BGC0000311 11932455
calcium-dependent antibiotic NRPS BGC0000315 12445768
chloroeremomycin NRPS na 10716695
complestatin NRPS BGC0000326 11447274
cyclomarin NRPS BGC0000333 18331040
cyclosporin NRPS BGC0000334 8376400
enniatin NRPS BGC0000342 8483420
enterobactin NRPS BGC0000343 10688898
exochelin NRPS BGC0000351 9720878
fengycin NRPS BGC0001095 10438779
gramicidin NRPS BGC0000367 1560782
HC-toxin NRPS na 1281482
lichenysin NRPS BGC0000381 9864322
penicillin NRPS BGC0000404 16713314
pristinamycin NRPS na 10449311
pyochelin NRPS BGC0000412 10555976
pyoverdine NRPS BGC0000413 15743962
surfactin NRPS BGC0000433 8355609
syringomycin NRPS BGC0000437 9830033
teicoplanin NRPS BGC0000441 15113000
thaxtomin NRPS BGC0000444 11115114
thiocoraline NRPS BGC0000445 16408310
tyrocidine NRPS BGC0000452 9352938
vibriobactin NRPS na 12040125
viomycin NRPS BGC0000458 12936980
albicidin PKS-NRPS BGC0001088 15077674
alterochromide PKS-NRPS BGC0000314 25140825
althiomycin PKS-NRPS BGC0001415 21626639
antimycin PKS-NRPS na 22861048
aspyridone PKS-NRPS BGC0000959 20828130
azinomycin PKS-NRPS BGC0000960 18635006
bacillaene PKS-NRPS BGC0001089 17886826
bactobolin PKS-NRPS BGC0000961 21615115
barbamide PKS-NRPS BGC0000962 12383521
bleomycin PKS-NRPS BGC0000963 11048953
C-1027 PKS-NRPS BGC0000965 12183628
caerulomycin PKS-NRPS BGC0000966 22591508
chaetoglobosin PKS-NRPS BGC0000968 17636916
chondramide PKS-NRPS BGC0000969 16793524
chondrochloren PKS-NRPS BGC0000970 19171307
cinnabaramide PKS-NRPS BGC0000971 21387511
clifednamide PKS-NRPS BGC0001553 29249153
colibactin PKS-NRPS BGC0000972 27547923
collismycin PKS-NRPS BGC0000973 22594451
combamide PKS-NRPS BGC0001556 29792712
crocacin PKS-NRPS BGC0000974 24981773
cryptophycin PKS-NRPS BGC0000975 17240975
curacin PKS-NRPS BGC0000976 21555588
cyclopiazonic acid PKS-NRPS BGC0000977 21608094
cylindrospermopsin PKS-NRPS BGC0000978 18065631
cystothiazole PKS-NRPS BGC0000982 16041144
cytochalasin PKS-NRPS BGC0000983 21983160
desmethylbassianin PKS-NRPS BGC0001136 21899331
didemnin PKS-NRPS BGC0000985 22458477
dihydromaltophilin PKS-NRPS BGC0000999 17074795
disorazole PKS-NRPS BGC0001093 16084035
emericellamide PKS-NRPS BGC0001290 18559263
eponemycin PKS-NRPS BGC0000345 24168704
epothilone PKS-NRPS BGC0000988 10662695
epoxomicin PKS-NRPS BGC0000346 24168704
equisetin PKS-NRPS BGC0001255 23614392
foxicin PKS-NRPS BGC0001598 28270798
frontalamide PKS-NRPS BGC0000996 20547882
fusarin PKS-NRPS BGC0001268 15368570
glidobactin PKS-NRPS BGC0000997 17564599
griseoviridin PKS-NRPS BGC0000459 23161816
guadinomine PKS-NRPS BGC0000998 23030602
hectochlorin PKS-NRPS BGC0001000 18001088
ikarugamycin PKS-NRPS BGC0001435 24706593
isoflavipucine PKS-NRPS BGC0001122 21236704
iturin PKS-NRPS BGC0001098 11591669
jamaicamide PKS-NRPS BGC0001001 15217615
kalimantacin PKS-NRPS BGC0001099 20189105
kedarcidin PKS-NRPS BGC0000081 23360970
kirromycin PKS-NRPS BGC0001070 18291322
lankacidin PKS-NRPS BGC0001100 18057700
leinamycin PKS-NRPS BGC0001101 12598647
leporin PKS-NRPS BGC0001445 26051490
leupyrrin PKS-NRPS BGC0000380 21365089
lipomycin PKS-NRPS BGC0001003 16723573
melithiazol PKS-NRPS BGC0001010 14583260
microcystin PKS-NRPS BGC0001017 10788786
mycosubtilin PKS-NRPS BGC0001103 10557314
myxalamid PKS-NRPS BGC0001022 11182319
myxothiazol PKS-NRPS BGC0001024 10601310
myxovirescin PKS-NRPS BGC0001025 16835859
nannocystin PKS-NRPS BGC0001212 26179970
nemamide PKS-NRPS na 27501395
nodularin PKS-NRPS na 15528492
nosperin PKS-NRPS BGC0001071 23898213
nostopeptolide PKS-NRPS BGC0001028 12853152
nostophycin PKS-NRPS BGC0001029 21948844
onnamide PKS-NRPS BGC0001105 15520376
oocydin PKS-NRPS BGC0001031 23012376
pactamide PKS-NRPS BGC0001726 28451290
padanamide PKS-NRPS na 23911586
paenilamicin PKS-NRPS BGC0001033 25044543
pederin PKS-NRPS BGC0001108 12381784
pellasoren PKS-NRPS BGC0001034 22488911
phyllostictine PKS-NRPS BGC0001741 28467083
pneumocandin PKS-NRPS BGC0001035 23688303
pseurotin PKS-NRPS BGC0001037 17722120
psymberin PKS-NRPS BGC0001110 19448639
puwainaphycin PKS-NRPS BGC0001125 25369527
pyridomycin PKS-NRPS BGC0001039 21454714
pyrronazol PKS-NRPS BGC0001750 28944573
ralsolamycin PKS-NRPS BGC0001754 26943626
rapamycin PKS-NRPS BGC0001040 7644502
rhizopodin PKS-NRPS BGC0001111 22278953
rhizoxin PKS-NRPS BGC0001112 17154220
rufomycin PKS-NRPS BGC0001763 28774961
salinosporamide PKS-NRPS BGC0001041 19590008
sanglifehrin PKS-NRPS BGC0001042 21416665
SGR810-815 PKS-NRPS BGC0001043 24305602
sirodesmin PKS-NRPS BGC0001044 15387811
skyllamycin PKS-NRPS BGC0000429 21456593
splenocin PKS-NRPS BGC0001216 25763681
spliceostatin PKS-NRPS BGC0001096 21291275
sporolide PKS-NRPS BGC0000150 18232689
streptolydigin PKS-NRPS BGC0001046 19875077
tenellin PKS-NRPS BGC0001049 17216664
thailanstatin PKS-NRPS BGC0001114 23517093
thalassospiramide PKS-NRPS BGC0001876 23270364
theonellamide PKS-NRPS BGC0001800 29439203
totopotensamide PKS-NRPS BGC0001807 29019409
tubulysin PKS-NRPS BGC0001053 15324808
virginiamycin PKS-NRPS BGC0001116 17350183
xenolozoyenone PKS-NRPS BGC0001187 26081635
xyrrolin PKS-NRPS na 22438295
yersiniabactin PKS-NRPS BGC0000467 9818149
zeamine PKS-NRPS BGC0001056 23349809
zearalenone PKS-NRPS BGC0001057 16262793
zorbamycin PKS-NRPS BGC0001058 19081934
zwittermicin PKS-NRPS BGC0001059 14711631
Aspergillus flavus FAS FAS na 25883274
Bacillus subtilis FAS FAS na 9384377
Caenorhabditis elegans FAS FAS na 9851916
Corynebacterium ammoniagenes FAS FAS na 8759839
Cryptosporidium parvum FAS FAS na 10693747
Escherichia coli FAS FAS na 9278503
Homo sapiens FAS FAS na 30272292
Melopsittacus undulatus FAS FAS na 28985565
Mycobacterium leprae FAS FAS na 8446027
Oryzias latipes FAS FAS na 26605048
Streptomyces coelicolor FAS FAS na 12000953
Thermomyces lanuginosus FAS FAS na 17431175
Toxoplasma gondii FAS FAS na 16902086

Database version: pksdb_20200830

DOWNLOAD BGC TABLE (tab-delimited format)
DOWNLOAD DOMAINS TABLE (tab-delimited format)
DOWNLOAD C domain sequences (fasta format)
DOWNLOAD KS domain sequences (fasta format)